Karunesh Ganguly, MD PhD
Neural Engineering and Plasticity Lab
Noon Lecture, Thursday January 23
MI 348 (Conference room)
A Systems Neuroscience Approach to Enhancing Motor Function After Injury
It is commonly hypothesized that restoration of normal neural dynamics in the injured brain can improve dexterous function. However, we lack a precise neurophysiological framework for such an approach. Here we show that neural sequencing linked to oscillatory dynamics plays an important role in the execution of skilled behaviors in both the intact and injured brain. We have chronically recorded local field potentials and spiking activity during motor training in both healthy and post-stroke animals. We found that task-related dynamics re-emerged with skilled performance and were a robust predictor of recovery. We further hypothesized that boosting oscillatory dynamics might improve function in animals with persistent deficits. Interestingly, we found that artificial electrical stimulation could augment neural dynamics and improve dexterous behavior. Together, our results suggest that oscillatory dynamics are essential for dexterous behaviors and may represent a novel target for modulation after injury.
The Center for Philosophy of Science at Pitt is hosting an Early Career Workshop on Tools and Technology in Neuroscience in January 24-25th, 2020. We are now accepting paper presentation and poster presentation abstracts for theoretical and philosophical topics. The deadline is August 15th.
See the Center’s website for details:
Technological innovation has always played a central role in neuroscientific experimentation and theorizing. Historically, Nissl and Golgi staining methods were crucial to allowing researchers to produce data bearing on the neuron doctrine. More recently, the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative, launched by former President Barack Obama and carried out with support from the NIH, NSF, DARPA, and IARPA, has directed resources into the development of new technologies in the hope that it will improve, or even revolutionize, our understanding of the brain. Additionally, new computational technologies potentially give insight into understanding how to link behaviour to neuroscience in ways that many hope will impact clinical practice.
The aim of this workshop is to explore how tools and technology have advanced neuroscience and cognitive science and consider their epistemological and broader philosophical implications. We are inviting abstract submissions linked to the workshop’s main questions:
1) How are new technologies in neuroscience assessed and revised?
2) How have new technologies in neuroscience advanced debates in (philosophy of) cognitive science?
We welcome any abstracts related to the overall theme of the workshop on tools and technology in neuroscience though preference may be given to those that directly address the main questions. In delimiting what counts as technology, we include both instruments and devices that can be portable to different experimental contexts, but also techniques, protocols and modelling tools. Examples could include (but are not limited to): CLARITY, Scale, SeeDB, fMRI, Deep Brain Stimulation, text/data mining methods, connectomics, MVPA, machine learning, Brain-computer interfaces, DREADDs, optogenetics and TMS. We hope this workshop encourages a substantive dialogue between researchers in neuroscience/cognitive science and philosophy. To facilitate this, each contributed talk will be paired with a commentator who is a senior faculty member in philosophy/neuroscience as appropriate.
We hope you will share this call with relevant early career researchers and consider submitting if you are an early career researcher.
Friday Seminar Series
Postdoctoral Researcher, Chu Lab
“PINK1-Mediated Neuroprotection Against Mutant Tau”
Senior Research Scientist, Johnson Lab
“Membrane to channel inhibition of NMDARs”
Join us in BST South Room S123 (NEW ROOM)
Friday January 24th @ 4pm
Enjoy GREAT science + Free Pizza and Beer