Papers for the month of May 2017


Zike I., Chohan M.O., Kopelman J.M., Krasnow E., Flicker D., Nautiyal K.M., Bubser M, Kellendonk C., Jones C.K., Stanwood G., Tanaka K.F., Moore H., Veenstra-VanderWeele J.

"OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior"
PNAS, 114:5719-5724

Mouse over here for a brief summary or click to open article in a new tab.Using a combined genetic and pharmacological challenge approach, we have demonstrated that ablated expression of EAAT3, a gene associated with OCD, diminishes basal ganglia-mediated repetitive behavior in mice. Targeted rescue of midbrain expression points to an impact of EAAT3 on dopaminergic neuron function, suggesting a model for synthesizing glutamate and dopamine effects on stereotypic behavior.


Suchitra Ramachandran

"Prediction Suppression and Surprise Enhancement in Monkey Inferotemporal Cortex."
Journal of Neurophysiology, Epub ahead of print:Epub ahead of print

Mouse over here for a brief summary or click to open article in a new tab.In predictive coding models of the visual system, neurons carry signed prediction error signals. We show here that monkey inferotemporal neurons exhibit prediction-modulated firing as posited by these models but that the signal is unsigned. The response to a prediction-confirming image is suppressed and the response to a prediction-violating image may be enhanced. These results are better explained by a model in which the visual system emphasizes unpredicted events than by a predictive coding model.


Ruff, DA, Cohen, MR

"A normalization model suggests that attention changes the weighting of inputs between visual areas"
PNAS, 114: E4085–E4094

Mouse over here for a brief summary or click to open article in a new tab.This study shows that normalization can explain interactions between neurons in different areas and provides a framework for using multiarea recordings and stimulation techniques to probe the neural mechanisms underlying neuronal computations.


Kanashiro, Tatajana; Ocker, Gabriel; Cohen, Marlene

"Attentional modulation of neuronal variability in circuit models of cortex"
Elife, 6:e23978

Mouse over here for a brief summary or click to open article in a new tab.We present a circuit model of cortex that captures attention mediated modulation of firing rates and correlated variability.


Suway S., Orellana J., McMorland A.,Fraser G., Velliste M., Liu Z., Kass R.

"Temporally Segmented Directionality in the Motor Cortex"
Cerebral Cortex, 1093:1-14

Mouse over here for a brief summary or click to open article in a new tab.Preferred directions of motor cortical neurons were found to change rapidly at discrete points in a reaching task.

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