Papers for the month of October 2019


Kuljis, D.A., Park, E., Telmer, C.A., Lee, J., Ackerman, D.S., Bruchez, M.P., Barth, A.L.

"Fluorescence-based quantitative synapse analysis for cell-type specific connectomics"
eNeuro, NA:ENEURO.0193-19.2019

Mouse over here for a brief summary or click to open article in a new tab.Anatomical methods for determining cell-type specific connectivity are essential to inspire and constrain our understanding of neural circuit function. We developed genetically-encoded reagents for fluorescence-synapse labeling and connectivity analysis in brain tissue, using a fluorogen-activating protein (FAP)- or YFP-coupled, postsynaptically-localized neuroligin-1 targeting sequence (FAP/YFPpost). We found that inhibitory inputs from fluorescently-labeled parvalbumin and somatostatin neurons are intermingled across the proximal dendrites, and that inputs from vasoactive-intestinal peptide neurons are rare for L2 pyramidal neurons.


Melville M., Hershock C. Rule G.

"Pairing practice and feedback with animations optimizes student learning in online module"
Journal of Computer Assisted Learning, EPub Ahead of print:1

Mouse over here for a brief summary or click to open article in a new tab.We evaluated the effects of different organization of material in an online module on student learning. Permutations that had questions as close as possible to animations maximized student learning.


"Zwitterionic polymer/polydopamine coating reduce acute inflammatory tissue responses to neural implants"
Biomaterials, 225:119519

Mouse over here for a brief summary or click to open article in a new tab.we report the development of the polydopamine (PDA)-poly (sulfobetaine methacrylate) (PSB) co-deposition method to coat the electrode surface for neural implant applications. Results demonstrated a stable and potent anti-fouling performance with the coating in vitro. In vivo evaluation revealed a significant reduction in inflammatory cell recruitment and activation, glial scar formation, and blood-brain barrier breach in coated implants compared to the controls after one week, while the neuronal distribution is not affected. This finding supports future investigation aimed at using PDA-PSB coatings to enhance the duration of neural electrode functionality.


"Editorial overview: Computational neuroscience"
Current Opinion in Neurobiology, 58:4

Mouse over here for a brief summary or click to open article in a new tab.Along with Mate Lengyel, I edited an issue of Current Opinion in Neurobiology focused on computational neuroscience.


Meier, M. H., Schriber, R. A., Beardslee, J., & Pardini, D.

"Associations between adolescent cannabis use frequency and adult brain structure: A prospective study of boys followed to adulthood"
Drug and alcohol dependence, 202:191-199

Mouse over here for a brief summary or click to open article in a new tab.Few studies have tested the hypothesis that adolescent cannabis users show structural brain alterations in adulthood. The present study tested associations between prospectively-assessed trajectories of adolescent cannabis use and adult brain structure in a sample of boys followed to adulthood.


Vargas, Robert

"Neural Representations of Abstract Concepts: Identifying Underlying Neurosemantic Dimensions"
Cerebral Cortex, 9:1-10

Mouse over here for a brief summary or click to open article in a new tab.Group-level factor analysis of the fMRI data revealed 3 semantic dimensions underlying the 28 abstract concepts, suggesting a brain-based ontology. The 3 dimensions corresponded to 1) the degree a concept was Verbally Represented; 2) whether a concept was External (or Internal) to the individual, and 3) whether the concept contained Social Content.


Calabro F, Murty VP, Jalbrzikowski M, Tervo-Clemmens B, Luna B

"Development of Hippocampal–Prefrontal Cortex Interactions through Adolescence"
Cerebral Cortex, 00:00

Mouse over here for a brief summary or click to open article in a new tab.We used a longitudinal neuroimaging dataset consisting of 480 fMRI scans from over 140 individuals scanned up to 10 times annually to characterize the development of hippocampal-prefrontal interactions through adolescence. We identify specific circuitry involving the hippocampus and ventromedial prefrontal cortex that shows marked age-related increases in connectivity strength, and whose maturation is linked to improvements on tasks assessing higher order cognitive functions.


Stuart, M.; Colaço, D.

"P-curving x-phi: Does experimental philosophy have evidential value?"
Analysis, 79:669–684

Mouse over here for a brief summary or click to open article in a new tab.To find out whether the significant findings in x-phi papers result from selection bias or p-hacking, we applied a p-curve analysis to a corpus of 365 x-phi chapters and articles. Our results suggest that this corpus has evidential value, although there are hints of p-hacking in a few parts of the x-phi corpus.


Boltze J, Mays RW, Taguchi A, Jolkkonen J, Savitz SI.

"Stem Cells as an Emerging Paradigm in Stroke 4: Advancing and Accelerating Preclinical Research."
Stroke, 50:3299-3306

Mouse over here for a brief summary or click to open article in a new tab.This paper reviews the discussions that were covered at the Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS) meetings. The main aim of these meetings was to accelerate the translational pathway for cell therapy in stroke to benefit patients.


Svetlana Pinet

"A critical review of the behavioral, neuroimaging, and electrophysiological studies of co-activation of representations during word production"
Journal of Neurolinguistics, 53:N/A

Mouse over here for a brief summary or click to open article in a new tab.A large body of behavioral, neuroimaging, and electrophysiological studies have investigated the consequences of co-activation of representations during word production. Despite such an amazing body of empirical data, it remains unclear how the production system handles co-activated items. In this paper, we review this evidence in a systematic way, and point out three common problems in the interpretations attached to these data. We then discuss alternative approaches which might be more fruitful in understanding the links between such data and the processes of spreading activation, selection, monitoring and control in language production.


Brown, Vanessa

"Neuroimaging Studies of Antidepressant Placebo Effects: Challenges and Opportunities"
Frontiers in Psychiatry, 10:669

Mouse over here for a brief summary or click to open article in a new tab.Over the last two decades, neuroscientists have used antidepressant placebo probes to examine the biological mechanisms implicated in expectancies of mood improvement.However, findings from these studies have yet to elucidate a model-based theory that would explain the mechanisms through which antidepressant expectancies evolve to induce persistent mood changes. Compared to other fields, the development of experimental models of antidepressant placebo effects faces significant challenges, such as the delayed mechanism of action of conventional antidepressants and the complex internal dynamics of mood. Still, recent neuroimaging studies of antidepressant placebo effects have shown remarkable similarities to those observed in other disciplines (e.g., placebo analgesia), such as placebo-induced increased µ-opioid signaling and blood-oxygen-level dependent (BOLD) responses in areas involved in cognitive control, the representation of expected values and reward and emotional processing. This review will summarize these findings and the challenges and opportunities that arise from applying methodologies used in the field of placebo analgesia into the field of antidepressant placebo effects.


Wirthlin M, Chang EF, Knörnschild M, Krubitzer LA, Mello CV, Miller CT, Pfenning AR, Vernes SC, Tchernichovski O, Yartsev MM

"A Modular Approach to Vocal Learning: Disentangling the Diversity of a Complex Behavioral Trait"
Neuron, 104:87-99

Mouse over here for a brief summary or click to open article in a new tab.What is vocal learning? Wirthlin et al. summarize behavioral and neurobiological data from a diversity of vocalizing species and propose a novel approach to the mechanistic study of this complex behavior.


Okonkwo, D., Puffer, R., Minhas, D., Beers, S., Edelman, K., Sharpless, J., Laymon, C., Lopresti, B., Benso, S., Puccio, A., Pathak, S., Ikonomovic, M., Mettenburg, J., Mathis, C., & Mountz, J.

"[18F]FDG, [11C]PiB, and [18F]AV-1451 PET imaging of neurodegeneration in two subjects with a history of repetitive trauma and cognitive decline"
Frontiers in Neurology, 10:1-9

Mouse over here for a brief summary or click to open article in a new tab.Trauma-related neurodegeneration can be difficult to differentiate from multifactorial neurodegenerative syndromes, both clinically and radiographically. We have initiated a protocol for in vivo imaging of patients with suspected TBI-related neurodegeneration utilizing volumetric MRI and PET studies, including [18F]FDG indexing cerebral glucose metabolism, [11C]PiB for Aβ deposition, and [18F]AV-1451 for tau deposition.


"What should cognitive science look like? Neither a tree nor physics"
Topics in Cognitive Science, 11:845-852

Mouse over here for a brief summary or click to open article in a new tab.While pointing out important features of cognitive science, Núñez et al. (2019) also argue prematurely for the end of cognitive science. I discuss problematic analytic features in the application of hierarchical cluster analysis to journal citation data. On the conceptual side, I argue that the research programs framework of Lakatos may not be so wisely applied to cognitive science. Further, the diversity of structure in cognitive science departments may represent a rational, strategic adaptation by an interdisciplinary department to cognitive and other resource challenges rather than the sign of low progress on a discipline.


Wiener, S.

"Language proficiency is only part of the story: Lexical access in heritage and non-heritage bilinguals"
Second Language Research, 0:1-15

Mouse over here for a brief summary or click to open article in a new tab.This study examined how language proficiency and age of acquisition affect a bilingual language user’s reliance on the dominant language during lexical access. Two bilingual groups performed a translation recognition task: Mandarin–English classroom bilinguals who acquired their dominant language (Mandarin) from birth and their non-dominant language (English) post-puberty through formal classroom instruction, and Mandarin–English heritage bilinguals who acquired their non-dominant language (Mandarin) at home from birth but became more dominant in another language (English) through society and peers.

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